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Artoindonesianin D: a new bioactive pyranoflavone derivative and chaplashin from Artocarpus maingayi

Euis Holisotan Hakim, Affrida, Eliza, Sjamsul Arifin Achmad, Norio Aimi, Mariko Kitajima, Lukman Makrnur, Didin Mujahidin, Yana Maolana Syah & Hiromitsu Takayama


Abstract. A new isoprenylated flavonoid, a pyranoflavone derivative 5'-hydroxycyclomorusin named artoindonesianin D (1), and an oxepinoflavone derivative chaplashin (2) were isolated for the first time, respectively from the root bark and root trunk of Artocarpus maingayi King. (Moraceae). This plant is locally known as Cubadak Utan, a rare species found in West Sumatera and endemic to Indonesia. The structure of both compounds were elucidated based on physical and spectroscopical data (MS, 1H and 13C NMR). Artoindonesianin D (1) and chaplashin (2) showed toxic effect against shrimp nauplii Artemia salina Leach.

Keywords: Artemia salina Leach; Artocarpus maingayi King; artoindanesianin D; chaplashin; Cubadak Utan; Moraceae; oxepinoflavone; pyranflavone

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