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Artonol B and Cycloartobiloxanthone from Artocarpus teysmanii MIQ

Lukman Makmur, Syamsurizal, Tukiran, Yoharmus Syamsu, Sjamsul Arifin Achmad, Norio Aimi, Euis Holisotan Hakim, Mariko Kitajima, Didin Mujahidin & Hiromits

 


Abstract. Two compounds, a xanthone lactone derivative, namely artonol B (1) and a furanodihydrobenzoxanthone derivative, namely cycloartobiloxanthone (2) had been isolated from Artocarpus teysmanii Miq. (Moraceae), locally known as Tipulu. The structures of both compounds were elucidated based on physical and spectroscopic data (MS, 1H and 13C NMR). Both artonol B (1) and cycloartobiloxanthone (2) showed strong toxicity against Artemia salina in the shrimp bioassay, and compound 2 also showed weak antimitotic activity against cdc2 kinase and cdc25 phosphatase as the targets.

Keywords: Antimitotic; Artocarpus teysmanii Miq.; artonol B; cdc2 kinase; cdc25 phosphatase; cycloartobiloxanthone; furanodihydrobenzoxanthone; Moraceae; tipulu; xanthone lactone

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