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Pyranoflavone and furanodihydrobenzoxanthone derivatives from Artocarpus lanceifolius

Euis Holisotan Hakim, Asnizar, Fera Kurniadewi, Tedi Abdul Ghofar, Sjamsul Arifin Achmad, Norio Aimi, Mariko Kitajima, Lukman Makmur, Didin Mujahidin, Hiromitsu Takaya

 


Abstract. Two pyranoflavone and furanodihydrobenzoxanthone derivatives, namely artelastin (1) and cycloartobiloxanthone (2), had been isolated respectivelfy from the wood and the tree bark of Artocarpus lanceifolius Roxb. (Moraceae), an endemic species of lndonesia, locally known as Keledang. The structures of both compounds were elucidated based on physical and spectroscopic data (MS, 1H and 13C NMR). Artelastin (1) strongly inhibited leucin amino acid transport in Bombyx mori midgut, while cycloartobiloxanthone (2) showed high toxicity against Artemia salina shrimp.

Keywords: Artemia salina; artelastin; Artocarpus lanceifolius Roxb.; Bombyx mori; furanodihydrobenzoxanthone; inhibition of leucin amino acid transport; keledang; pyranoflavone

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