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Artocarpin ad Heteroflavanone-A, Two Bioactive Flavonoids from Artocarpus champeden

Euis Holisotan Hakim, Emilia Evi Marlina, Didin Mujahidin Sjamsul Arifin Achmad, Emilio L. Ghisalberti & Lukman Makmur


Abstract. An isoprenylated flavone, 3-(γ,γ-dimethylallyl)-6-(3-methyl-1-butenyl)-7-methoxy-5,2,4-trihydroxyflavone or artocarpin (1), together with rare flavanone derivative, 5-hydroxy-7,2,4,6-tetramethoxyflavanone or heteroflavanone-A (2) were isolated from the wood and the tree bark of Arocarpus champeden Spreng (Moraceae), an endemic plant of Indonesia, locally known as cempedak. The structures of both compounds were elucidated based on physical and spectroscopic data. Both flavonoids inhibited the amino acid transport in Bombyx mori midgut, while artocarpin (1) also showed high toxicity against Artemia solina shrimp.

Keywords: Artemia salina; Artocarpus champeden Spreng; artocarpin; Bombyx mori; cempedak; heteroflavanone A; inhibition of amino acid transport; isoprenylated flavone,

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