Artocarpin ad Heteroflavanone-A, Two Bioactive Flavonoids from Artocarpuschampeden
Euis Holisotan Hakim, Emilia Evi Marlina, Didin Mujahidin Sjamsul Arifin Achmad, Emilio L. Ghisalberti & Lukman Makmur
Abstract. An isoprenylated flavone, 3-(γ,γ-dimethylallyl)-6-(3-methyl-1-butenyl)-7-methoxy-5,2’,4’-trihydroxyflavone or artocarpin (1), together with rare flavanone derivative, 5-hydroxy-7,2’,4’,6’-tetramethoxyflavanone or heteroflavanone-A (2) were isolated from the wood and the tree bark of Arocarpuschampeden Spreng (Moraceae), an endemic plant of Indonesia, locally known as cempedak. The structures of both compounds were elucidated based on physical and spectroscopic data. Both flavonoids inhibited the amino acid transport in Bombyxmori midgut, while artocarpin (1) also showed high toxicity against Artemiasolina shrimp.
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