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Pengaruh Kromium Klorida terhadap Perkembangan Pralahir Mencit (Mus musculus) Swiss Webster

Lucia Maria Santoso, ri Sudarwati & Lien A. Sutasurya


Abstract. Chromium chloride was injected intraperitoneally at 15, 22.5, and 30 mg Cr/kg body weight to pregnant mice on the 8th, 10th, or 12th gestation day. Control and treated mice were sacrificed on the 18th gestation day, and the examination on incidences of intrauterine death, fetal weight, external, internal, and skeletal malfbrmations were performed. The results revealed that there was a significant increase in embryonic resorption, a highly significant reduction in fetal weight, significant reduction in the ossification of the cervical and sacrocaudal vertebral bodies, tarsal bones, and phalanges of the hind limbs. Administration of chromium on the 8th and 12th day of gestation showed significant incidences of exencephaly and cleft palate, respectively. In order to figure out the passage of chromium during 24 hours after administration, analysis using Atomic Absorption Spectrofotometry (AAS) was performed, and the content of chromium was determined in the maternal blood, placenta, and fetuses. From the analysis it was obvious that chromium was transferred and accumulated in the fetuses, and the placenta tended to retain chromium.


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