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Effect of Basazinon 45/30 EC on the Postnatal Development of the Albino Mouse (Mus Musculus) Swiss Strain

Tien W. Suryono, Sri Sudarwati & Lien A. Sutasurya


Abstract. Basazinon 45/30 EC of 22 mg/kg b.w. were administered daily by gavage to pregnant mice on day 15 of gestation to the day of weaning (21 days old). Several physical and sexual developmental criteria and the reproductive ability of the F1 generation were observed. The mean body weight of the young during the period of lactation and the first week after weaning were significantly lighter (p < 0.05 and p < 0.01) than that of the controls, while the mean birth weight were not different. The reflex ability in turning the body from supine to prone position, the first testicle descent and the first estrous, occured significantly later in experimental young (p < 0.05 and p < 0.01). No significant deviation in the reproductive ability and other developmental criteria were found.

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