DOI Number : 10.5614/itbj.sci.2003.35.2.1
Hits : 25

Bergenin, Suatu Dihidroisokumarin dari Kayu dan Kulit Batang Shorea stenoptera Burck

Euis Holisotan Hakim1, Rudiyansyah1, Iqbal Musthapa1 & Koichi Takeya2

1Kelompok Penelitian Kimia Organik Bahan Alam, Departemen Kimia,

Fakultas Matematika dan Ilmu Pengetahuan Alam, Institut Teknologi Bandung,

Jalan Ganeca 10, Bandung 40132

2Tokyo University of Pharmacy & Life Science,

 Harinouchi 1432-1, Hachioji, Tokyo 192-0392, Japan


Abstract.

Bergenin, a dihydroisocoumarin derivative of glucopyranosyl gallic acid had been isolated for the first time from ethyl acetate extracts of the heartwood and tree bark, together with (-)-a-viniferin from the tree bark of Shorea stenoptera.  The structure of bergenin was elucidated based on analysis of spectroscopic data UV, IR, MS, 1H and 13C NMR. Bergenin showed weak cytotoxic activity against murine leukemia P-388 cells (IC50 >100 g/mL), and also weak toxicity against Artemia salina shrimps (LC50 >500 g/mL).



Keywords: Artemia salina; Bergenin; Murine leukemia P-388; Shorea stenoptera; (-)-alpha-Viniferin.

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