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Bergenin, Suatu Dihidroisokumarin dari Kayu dan Kulit Batang Shorea stenoptera Burck
Euis Holisotan Hakim1, Rudiyansyah1, Iqbal Musthapa1 & Koichi Takeya2
1Kelompok Penelitian Kimia Organik Bahan Alam, Departemen Kimia,
Fakultas Matematika dan Ilmu Pengetahuan Alam, Institut Teknologi Bandung,
Jalan Ganeca 10, Bandung 40132
2Tokyo University of Pharmacy & Life Science,
Harinouchi 1432-1, Hachioji, Tokyo 192-0392, Japan
Abstract. Bergenin, a dihydroisocoumarin derivative of glucopyranosyl gallic acid had been isolated for the first time from ethyl acetate extracts of the heartwood and tree bark, together with (-)-a-viniferin from the tree bark of Shorea stenoptera. The structure of bergenin was elucidated based on analysis of spectroscopic data UV, IR, MS, 1H and 13C NMR. Bergenin showed weak cytotoxic activity against murine leukemia P-388 cells (IC50 >100 µg/mL), and also weak toxicity against Artemia salina shrimps (LC50 >500 µg/mL).
Keywords: Artemia salina; Bergenin; Murine leukemia P-388; Shorea stenoptera; (-)-alpha-Viniferin.
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