DOI Number : 10.5614/j.math.fund.sci.2014.46.3.2
Hits : 6

Antibacterial Curcuma xanthorrhiza Extract and Fractions

Hartiwi Diastuti1,3, Yana M. Syah1*,Lia D. Juliawaty1, Marlia Singgih2

1Organic Chemistry Division, InstitutTeknologi Bandung,
Jalan Ganesha 10, Bandung 40132, Indonesia
2School of Pharmacy, Institut Teknologi Bandung,
Jalan Ganesha 10, Bandung, Indonesia
3Chemistry Program, Universitas Jenderal Soedirman,
Jl. HR Boenyamin 708 Purwokerto 53122.Indonesia
*Email: yana@chem.itb.ac.id


Abstract. An acetone extract of Curcuma xanthorrhizarhizomes and the n-hexane and chloroform fractions obtained from it were tested on eight pathogenic bacteria. The results showed that the acetone extract and the n-hexane fraction exhibited significant activities against Bacillus subtilis, Pseudomonas aeruginosa, and Staphylococcus aureus, and weak activities againstShigelladysenteriae and Vibrio cholerae. They were inactive against Escherichia coli, Enterobacteraerogenes andSalmonella thypi, while the chloroform fraction was devoid of activities. NMR analysis disclosed the presence of α-curcumene,xanthorrhizol and an unknown monoterpene in the n-hexane fraction. In the chloroform fraction, curcumin was found to be the main compound, together with xanthorrhizol as a minor compound. These results suggest that the antibacterial potency of acetone extract of C. xanthorrhizais contained in the n-hexane fraction, in which the active constituents areterpenoid compounds. This is the first report of the use of NMR analysis for compound identification contained in an extract or fractions of C. xanthorrhiza.

Keywords: α-curcumene; antibacterial; curcuma xanthorrhiza; curcumin; xanthorrhizol; NMR analysis; TOCSY-1D.

Download Article
 
Bahasa Indonesia | English
 
 
 

Notification:

Begin on 10 October 2014 this website is no longer activated for article process in Journal of Mathematical and Fundamental Sciences, Journal of Engineering and Technological Sciences, Journal of ICT Research and Applications and Journal of Visual Art and Design. The next process will be proceeded under new website at http://journals.itb.ac.id.

For detail information please contact us to: journal@lppm.itb.ac.id.

 
       
       
       ITB Journal Visitor Number #26339897       
       Jl. Tamansari 64, Bandung 40116, Indonesia Visitor IP Address #       
       Tel : +62-22-250 1759 ext. 121 © 2011 Institut Teknologi Bandung       
       Fax : +62-22-250 4010, +62-22-251 1215 XHTML + CSS + RSS       
       E-mail : journal@lppm.itb.ac.id or proceedings@lppm.itb.ac.id Developed by AVE