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Antidiabetic Effects of a Decoction of Leaves of Sansevieria trifasciata in Alloxan-Induced Diabetic White Rats (Rattus norvegicus L.)
Nur Qomariyah1, Mulyati Sarto2 & Rarastoeti Pratiwi2
1Postgraduate Student, Faculty of Biology,Universitas Gadjah Mada,
Bulaksumur, Yogyakarta 55281, Indonesia
2Faculty of Biology, Universitas Gadjah Mada, Bulaksumur,
Yogyakarta 55281, Indonesia
E-mail: nurq.biounesa@yahoo.com
Abstract. Diabetes mellitus is a metabolic disorder characterized by hypergly-cemic episodes. One approach for controlling hyperglycemia is to use natural compounds derived from plants, such as Sansevieria trifasciata leaves, which are presumed to contain hypoglycemic agents. Sansevieria trifasciata leaves are widely used by the Sabah community in Malaysia. The aim of the present study was to investigate the effects of a decoction of Sansevieria trifasciata leaves on blood glucose levels and the density of granules in pancreatic β cells in alloxan-induced hyperglycemic rats. This study used a completely randomized design and 30 male Wistar rats that were 2 months old, and had a body weight in the range of 150-200 gram. The rats were divided into a group of normal rats as the control group and five groups of alloxan-induced hyperglycemic rats, each with 5 animals per group. The five groups of hyperglycemic rats were administered by aquadest, respectively: saline, as a diabetic control; 5mg/kg bw glibenclamide; 100 mg/kg bw, 150 mg/kg bw, and 200 mg/kg bw of the S.trifasciata leaf decoction, using 1 ml per 200 g body weight for 30 days. Histological examination of the pancreas was performed by paraffin section and Victoria Blue staining. The results of this study show that all doses of the Sansevieria trifasciata leaves decoction decreased the level of blood glucose and increased the granule density in the β cells of the islets of Langerhans of the alloxan-induced hyperglycemic (diabetic) rats.
Keywords: alloxan diabetes; blood glucose; β granule cells; Sansevieria trifasciata.
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