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Flavonoids from Macaranga lowii
Widiastuti Agustina, Lia D. Juliawaty, Euis H. Hakim & Yana Maolana Syah1
Organic Chemistry Division, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia
1E-mail: yana@chem.itb.ac.id
Abstract. A new isoprenylated dihydroflavonol derivative, macalowiinin (1), together with two known flavonoids 4’-O-methyl-8-isoprenylnaringenin (2) and 4’-O-methyl-5,7,4’-trihydroxyflavone (3) (= acasetin), have been isolated from the methanol extract of the leaves of Macaranga lowii. The structures of these compounds were determined based on UV, NMR, and mass spectral data, and optical rotation. Preliminary cytotoxic evaluation of compounds 1 – 3 against P-388 cells showed that compound 3 is the most active with IC50 was 58.7 mM.
Keywords: acasetin; cytotoxicity; isoprenylated dihydroflavonol; macaranga lowii; macalowiniin; 4’-O-methyl-8-isoprenylnaringenin; P-388 cells.
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